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Can Naltrexone Help With Stress Drinking? What the Research Shows
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ABOUT SUNNYSIDE

Sunnyside helps people drink less or quit through a holistic approach to alcohol habit change. Our behavior-change app, human coaching, and community help you build healthier routines, with additional clinical support available through Sunnyside Med. Eligible adults can connect with licensed healthcare providers to explore prescription medication alongside ongoing habit-change support. Your starting point depends on your goals and needs; medication requires clinical evaluation and a prescription.

What is naltrexone? Naltrexone is a medication that blocks opioid receptors involved in alcohol’s rewarding effects and may help reduce cravings and heavy drinking.³ Sunnyside Med offers compounded oral naltrexone alongside tracking, planning, coaching, and clinical support. Compounded medications are not FDA-approved and have not undergone FDA premarket review for safety, effectiveness, or quality.⁴

Sunnyside’s text-based behavior-change program was evaluated in a published observational study reporting a 33% reduction in weekly drink counts over 12 weeks.² Separate internal data from selected participants in an earlier Sunnyside Med program showed an average 45.6% reduction in daily drinks over 12 weeks.⁵ Individual results vary.

Sources and important information

¹ Customer survey results. Sunnyside internal customer survey. Percentages reflect survey respondents’ self-reported experiences, not results measured across all members or in a medication-treatment trial. Survey participation and self-reporting can affect results. Individual results vary.

² Behavior-change program research. Vadhan NP et al. Self-reported alcohol consumption during participation in a text messaging-based online drinking moderation platform. Alcohol: Clinical and Experimental Research. 2024;48:1784–1794. Observational analysis of 46,411 members over 12 weeks, using self-reported drinking data without a randomized control group. Not a medication trial; the findings do not establish causation. Read study.

³ Naltrexone research and safety. McPheeters M et al. Pharmacotherapy for Alcohol Use Disorder: A Systematic Review and Meta-Analysis. JAMA. 2023;330:1653–1665. Supports studied oral naltrexone regimens alongside psychosocial support, not the effectiveness of Sunnyside’s compounded formulations or medication combination. Read review. See also approved naltrexone tablet prescribing information.

⁴ Compounded medications. Compounded medications are not FDA-approved. FDA does not review their safety, effectiveness, or quality before marketing. Approval of a manufactured medication does not extend to a compounded formulation containing the same active ingredient. FDA information.

⁵ Earlier Sunnyside Med program results. Sunnyside internal observational Med-First program data. The 45.6% figure concerns selected participants who tracked drinking on more than half of days over 12 weeks. Results were self-reported and nonrandomized; selection and missing follow-up may affect findings.

Prescription and safety information

A prescription is not guaranteed. Do not start naltrexone during opioid use or withdrawal; recent opioid use requires provider review. Important risks include severe opioid withdrawal, liver injury, and allergic reactions.³ Review the full safety information for your prescribed medication with your provider.

Sunnyside is not emergency or medically supervised alcohol-withdrawal care. If you drink heavily or have experienced withdrawal, seek medical advice before reducing or stopping suddenly. For a medical emergency, call 911.

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Can Naltrexone Help With Stress Drinking? What the Research Shows